Apoptosis Apoptose

Apoptosis or Programmed Cell Death is basically cellular suicide. Apoptose eller programmeret Celledød er grundlæggende cellulære selvmord. This interesting and very important cellular phenomena is the topic of this website. Dette interessante og meget vigtige cellulære fænomener er emnet for denne hjemmeside.

Apoptosis is the term given when programmed cell death (PCD) occurs in multicellular organisms. Apoptose er det udtryk gives, når programmeret celledød (PCD) forekommer i flercellede organismer. Apoptosis is one of the main types of programmed cell death which involves a series of biochemical events leading to specific cell morphology characteristics and ultimately death of cells. Apoptose er en af de vigtigste former for programmeret celledød, der indebærer en række biokemiske begivenheder, der førte til specifikke celle morfologi egenskaber og i sidste ende død celler. Characteristic cell morphology of cells undergoing apoptosis include blebbing, changes to the cell membrane such as loss of membrane asymmetry and attachment, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation. Karakteristiske celle morfologi af celler undergår apoptose omfatte blebbing, ændringer til celle membranen såsom tab af membranen asymmetri og udlæg, celleterapi krympning, nuklear fragmentering, chromatin kondensvand, og kromosomal DNA fragmentering. Apoptosis differentiates from necrosis as the processes associated with apoptosis in disposal of cellular debris do not damage the organism in apoptosis. Apoptose skelnes fra nekrose som processerne i forbindelse med apoptose i bortskaffelse af cellulære vragrester ikke skader organismen i apoptose.

Necrosis is a form of traumatic cell death that results from acute cellular injury. Nekrose er en form for traumatisk celledød, at resultater fra akutte cellulær skade. Apoptosis in contrast to necrosis, confers advantages during an organism's life cycle. Apoptose i modsætning til nekrose, giver fordele i en organisme livscyklus. For instance during the development of the fetus in the mother, the differentiation of fingers and toes occurs because cells between the fingers apoptose with the end result that the digits are separate. For eksempel under udviklingen af fosteret i moderens, differentieringen af fingre og tæer opstår, fordi cellerne mellem fingrene apoptose med slutresultatet, at cifre er adskilt. Approximately between 50 billion and 70 billion cells die each day due to apoptosis in the average human adult. Ca. mellem 50 milliarder og 70 milliarder celler dør hver dag som følge af apoptose i den gennemsnitlige menneskelige voksen. In a year, this amounts to the proliferation and subsequent destruction of a mass of cells equal to an individual's body weight. I et år, svarer det til spredning og efterfølgende destruktion af en masse af celler svarende til en persons kropsvægt.

Since the 1990's research has increased substantially in the field of apoptosis. Siden 1990's forskning er steget betydeligt inden for apoptose. It has been shown that defective apoptotic processes in humans and animals are related to a variety of diseases. Det er blevet påvist, at defekte apoptotic processer hos mennesker og dyr er knyttet til en række forskellige sygdomme. Excessive apoptosis causes hypotrophy, such as in ischemic damage, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. Overdreven apoptose årsager hypotrophy, såsom iskæmisk skade, mens et utilstrækkeligt beløb, der resulterer i en ukontrolleret celledelingen, såsom cancer.

Apoptosis in Cardiomyocytes Apoptose i Cardiomyocytes

Cardiomyocyte Apoptosis - Primed for Cell-Death Cardiomyocyte apoptose - grundlakeret for celle-død